8 Cardarine Side Effects That You Should Know

Medically reviewed by G. Liakeas, MD FACT CHECKED

Cardarine is the most potent SARM for burning fat. There has been a lot of talk about cardarine and how it may be used to improve performance and lose weight.

SARMs are used by athletes and bodybuilders to boost their ability to burn fat because they are similar to steroids but have fewer adverse effects.

Cardarine is a synthetic substance that functions as a metabolic regulator. Steroids also do this, but they are not selective, binding to all of the body’s androgen receptors simultaneously.

This is thought to be one of the factors that contribute to them having more adverse effects than SARMs. Cardarine does not interact at all with androgen receptors.

By interacting with the androgen receptors in bone and muscle, selective androgen receptor modulators (SARMs) strengthen bones and increase protein synthesis.

Cardarine is a member of a group of medicines known as peroxisome proliferator-activated receptor (PPAR) agonists. With this medication, side effects are a serious issue.

Nevertheless, despite many warnings, many continue to use Cardarine and buy it on the illicit market. Cardarine has been linked to several unfavorable side effects, according to comments made on bodybuilding sites.

In this article, we will be looking at some of the many side effects associated with Cardarine.

Side Effects Of Cardarine

Here are some of the side effects of cardarine:

  1. Might Increase Liver Toxicity

    The liver is known to be harmed by cardarine in many ways. During some of the trials, there were slight variations in liver results.

    Again, additional knowledge is required to determine exactly what effects, if any, Cardarine may have on the liver. Although persons who already have liver issues may be more susceptible to risky changes in liver enzyme levels.

    Therefore, until additional information is available, you might want to reconsider using Cardarine if you already have a liver issue.

    It is strongly advised against taking numerous prescription drugs (especially antidepressants) and drinking alcohol while using Cardarine because doing so can affect your liver.

    In some situations, Cardarine may put your liver in higher danger. When you combine it with one or more additional substances, such as SARMs or steroids, you risk it even more.

    Cardarine encourages cellular proliferation (cell division and growth), therefore when coupled with other substances that already have a bad effect on the liver, this severe adverse effect may be compounded and made worse.

    The levels of liver enzymes will significantly alter for the worse as a result, and in severe situations, liver failure may result.

    If you’re set on stacking Cardarine with liver-stressing substances, attempt to adhere to the shortest cycle possible to minimize this danger because Cardarine could aggravate liver toxicity.

  2. Changes In Body Sugar And Fat

    Sugar levels may increase when cardarine is consumed. Type two diabetes can have severe consequences from it. Patients must therefore ensure that their sugar is routinely monitored and checked while using cardarine.

    As soon as Cardarine is removed, sugar levels will return to normal. Cardarine dramatically raises cortisol levels, which causes a significant increase in weight.

    Adrenal suppression can lead to adrenal insufficiency and atrophy. The adrenal glands, which produce cortisol, may shut down as the body’s cortisol levels rise.

    An overabundance of cortisol in the body can lead to Cushing syndrome, a rare disease that redistributes fat throughout the entire body.

    Cushing syndrome is indicated by the distribution of fatty tissue around the waist, between the shoulder blades, and over the face.

  3. Causes Hair Loss

    After a certain age, every male begins to lose hair. The causes of hair loss may include environmental, hereditary, etc.

    Cardarine, however, might contribute to male pattern baldness. Cardarine has a unique role, and as a result, it lowers the levels of various hormones in your body.

    Hair loss may be caused by an unequal and unhealthy level of sex hormones. Additionally, a longer-term Cardarine overdose may potentially contribute to male pattern baldness.

  4. May Impact The Menstrual Cycle

    Women who use cardarine may experience irregular menstrual cycles. A woman’s body produces more androgen because of cardarine.

    An excess of androgen hormones in women’s bodies may cause hormonal disorders, such as the highly prevalent PCOS (polycystic ovarian syndrome).

    Menstrual cycles are irregular in polycystic ovarian syndrome sufferers and may come late or early. Women who have irregular menstrual cycles often experience discomfort, unpleasantness, and pain.

    Additionally, women’s hormonal illnesses like PCOS may have several other underlying medical issues.

  5. Suppresses Natural Production Of Testosterone

    Your body fills up with androgen when you use cardarine, negating the requirement for your body to produce its natural androgens. As a result, when androgen levels rise, your body is told to stop producing its testosterone.

    The body’s requirement for natural androgens is reduced when it is overflowed with cardarine because they bind to the androgen receptor.

    Additionally, while androgen levels are at their highest, your body won’t use extra energy on manufacturing testosterone.

    Thus, by doing this, your body may limit its natural testosterone production while also beginning to show signs of low testosterone. The impact of low testosterone is already well known.

  6. Might Cause Cancer

    This is a murky topic because, on the one hand, doctors indicate that Cardarine can prevent the growth of cancer cells in the breast and colon tissues, and other parts of your body.

    On the other hand, cancer is thought to be caused by cardarine. Cardarine’s rapid induction of cancerous tumors on several animal organs led a major manufacturer known as GSK to halt the development of the drug in 2007.

    This discovery led to the development of the Cardarine cancer theory. Yes, this has only been observed in animals. However, you can’t completely disregard this information given that Cardarine has never been tested on humans.

  7. Increases Blood Pressure

    Cardarine can significantly reduce the good cholesterol HDL which raises the risk of hypertension. Cardarine’s oral delivery may be to blame for this cardiovascular strain.

    Oral steroids are well known for their detrimental effects on lipid levels. Additionally, as low aromatization is known to enhance HDL, cardarine may also be to blame for unhealthy cholesterol levels.

    Regular cardio can be incorporated into cardarine users’ cycles together with fish oil substances to battle HDL declines and stop heart damage.

  8. Might Cause Insomnia

    A rise in adrenaline output and a stimulating effect on the central nervous system are both suggested by some cardarine users’ reports of sleeplessness.

    By taking their medication earlier in the day, preferably in the morning, users can give their CNS plenty of time to regulate before bed, perhaps avoiding this side effect.

    Although the CNS might become more stimulated, this effect is thought to not be too strong. Cardarine, as a result, does not have the jittery effects of more well-known, thermogenic fat burners like clenbuterol.

    Instead, consumers’ overall well-being rises while their energy levels on cardarine remain consistent (avoiding any crashes).

  9. Steroid Withdrawal Effects

    The regular usage of Cardarine could also lead to steroid withdrawal issues if one even tries to stop the consumption. As a result, there is a high chance that the consumer may want to undergo post-cycle therapy so that their hormone production can start again.


There are extremely few adverse consequences from cardarine. There have been a few negative effects linked to the use of this medication where the patient experienced one of the problems listed above while using cardarine.

The problems weren’t definitively linked to cardarine usage. It might have been a coincidence unrelated to the usage of cardarine. Despite this, it was labeled as a cardarine side effect, even though these adverse effects are extremely rare.

As long as you take the supplement carefully and by your doctor’s instructions, cardarine has the potential to offer you a host of advantages.

For the best effects, cycle properly, do not exceed the dosage, and make sure you are eating sensibly and exercising.

Cardarine is a terrific option for amateur athletes and people who want to build lean muscle and shed weight because it can promote fat reduction and boost endurance.

As always, confirm that the manufacturer from which you are purchasing your cardarine supplements is a reputable one.

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