DMAA: What Is It, Uses, Benefits, Side Effects And More

Medically reviewed by Maria Sarino, MD FACT CHECKED

Dimethylamylamine is a medication that is synthesized in a lab. Originally, it was used as a nasal decongestant.

Dimethylamylamine is available as a dietary supplement for the treatment of attention deficit hyperactivity disorder, which is also known as ADHD.

Dimethylamylamine also aids in bodybuilding, weight loss, and sports performance enhancement. Some brands claim that rose geranium oil naturally contains Dimethylamylamine.

On the label of supplements containing this ingredient, you could see geranium stems, rose geranium, or geranium oil.

However, laboratory testing indicates that this substance is unlikely to be derived from this natural source.

It is thought that instead of obtaining this substance naturally, these makers intentionally added it to the supplement.

In many parts of the world, Dimethylamylamine is classified as a controlled substance and is not allowed in natural health products or dietary supplements.

In this article, we will be looking at what DMAA is, its benefits, side effects, and a lot more.


DMAA, or Dimethylamylamine, has been used in weight loss and sports performance products, many of which are advertised as dietary supplements.

As DMAA is not a dietary element, items containing it that are sold as dietary supplements are prohibited and their marketing is illegal.

DMAA is also known as geranium extract or methylhexanamine. It is often marketed as a natural stimulant. However, people are unaware of any scientific evidence that DMAA occurs naturally in plants.

Although DMAA was once licensed as a nasal decongestant, it is no longer permitted for this use, and there is no medical use for it currently.

Consumers could be in danger from DMAA, especially when combined with certain stimulant chemicals, such as caffeine.

Taking DMAA might cause cardiovascular issues, such as heart attack, shortness of breath, and chest tightness. It might also raise blood pressure.

Due to the health concerns posed by dietary supplements containing DMAA, the FDA urges people not to use or buy them.

What Does DMAA Do?

Although the specific mechanism of action of DMAA is unknown, it mimics the effects of human hormones, such as adrenaline.

DMAA raises blood pressure by acting on blood vessels and boosts energy by acting on the brain’s reward system, according to research.

It induces the flight-or-fight response, similar to different stimulants, by imitating adrenalin. This might result in subjective misuse and high.

It is usually advertised as a legal high. It has been used in the military, for weight reduction, to boost energy during exercises, and as party pills.

DMAA is a performance enhancer that has been banned by several sporting organizations.

DMAA behaves similarly to methamphetamine and cocaine, has significant addiction potential, and might cause major negative effects, according to studies.

DMAA Benefits

Here are some of the benefits of DMAA:

  • Weight Loss

    When you commit to losing weight, you will feel and look so much better than you do currently. The difficulty, of course, is that losing weight is difficult, especially if you have gained a lot of weight in recent years.

    However, DMAA might be able to assist you in losing the weight you are carrying currently. You should be cautious about the weight loss supplements that you take.

    You might not be able to take each of them as they are not healthy. However, if you are willing to do some research, you should be able to find that DMAA might help you get started on your weight loss journey.

  • Good Athletic Performance

    If you enjoy working out to stay in shape, or participating in athletic tournaments, consuming DMAA might aid in your body’s recovery after a strenuous workout.

    When you have the correct minerals and vitamins on hand, you would not have to worry about your bones, muscles, or tendons aching too much.

    DMAA is beneficial for those who want to maintain healthy and strong bones. They are also good choices for athletes who wish to avoid a significant inflammatory response after a competition.

    You might want to look for DMAA supplements which are specifically developed to assist athletes in achieving their best results.

    DMAA normally has the minerals and vitamins you might need to safeguard your body and everything inside of it when you are working out for whatsoever reason.

  • Good Cognitive Performance

    It is natural for certain of your cognitive talents to start to decrease as you become older. Your memory might not be as sharp as it once was.

    You are going to have to put up with this for a while. However, DMAA could help you reverse this tendency and avoid feeling like you are losing your ability to think and comprehend information.

    When you look for DMAA supplements through a reputable company, you might notice that several supplements contain specific cognitive formulae which might be able to assist you.

    Some of your cognitive talents might be regained as you become older, or you might lose them completely.

    You do not have to put up with the aggravation which usually comes with the loss of cognitive capacities as you become older. By investing in the correct minerals and vitamins, you might try to recover your memory and brain activity.

  • Burns Fat

    OxyELITE Pro is a DMAA-containing dietary supplement. It has helped 30 healthy adults lose body fat by giving them a pill per day for one week, according to randomized controlled research.

    In the randomized controlled experiment, it also enhanced body temperature and fat breakdown in 15 adults, which is expected to help in long-term fat loss.

DMAA Pre-Workout

When you start a fitness routine or a new sport, your ultimate goal is to achieve excellence. You look for techniques and everything else which could bring you there as quickly as possible.

In recent years, studies have been developed to help people attain their goals and improve their performance. Pre-workout supplements are what they are called.

They include several components which have an impact on the cerebral function and the skeletal and muscular systems.

One of these components is 1,3-Dimethylamylamine. Its popularity as a brain stimulant stems from its potential to boost people’s overall performance, strength, energy, and stamina.

DMAA Side Effects 

Here are some of the side effects of DMAA:

  • Liver Damage

    In a 2013 study, 35 people were hospitalized for liver damage after using OxyELITE Pro, a nutritional supplement containing DMAA.

    One individual died and two needed liver transplants out of the 35. These participants were taking the prescribed daily dose, which is 1-2 pills or scoops.

    However, 26 of the participants were using OxyELITE Pro without DMAA. These are super thermo capsules. It is impossible to say which component was poisonous.

  • Bleeding In The Brain

    There have been at least five instances of people experiencing brain hemorrhage as a result of using DMAA. The users admitted to using DMAA with caffeine or alcohol regularly.

    After taking the recommended dose of 2 scoops of Jack3d, which is a nutritional supplement containing DMAA, a 28-year-old healthy male got a brain hemorrhage and severe headache, according to research.

  • Interactions Between Drugs

    DMAA inhibited the activity of two key enzymes, 3A4 and cytochrome P450 2D6 in a cell study, which breaks down about 26% of routinely used medicines.

    They aid in the removal and breakdown of cardiac medicines, antipsychotics, antidepressants, and opioids. Drugs might pile up in the body and reach dangerously high levels if they are inhibited, potentially causing liver damage.

  • Blood Pressure And Heart Rate Rise

    In a randomized controlled experiment, 15 healthy people who took one capsule of a dietary supplement containing DMAA, OxyELITE Pro, saw an increase in blood pressure and heart rate.

    The researchers looked at 58 cases of DMAA exposure in healthy persons for side effects, the majority of which (85%) came from using OxyELITE Pro before it was prohibited.

    A noticeable rise in heart rate was observed in nearly a third of the patients. However, this effect might be attributable to certain drugs, such as caffeine.

    In 6 healthy adults, a dose of 26 mg of DMAA did not affect blood pressure or heart rate.

Is DMAA Illegal?

The use of DMAA has been linked to possibly deadly adverse effects. Therefore, some countries, including Canada and the United States, have made DMAA-containing goods illegal.

When introducing a new supplement to the market, it is always essential to do as much research as possible.

While it might be tempting for some to try something new as there is a lot of buzz about it in the market, it is always advisable to take supplements cautiously.

Perhaps a safe version might emerge in the future, but taking or promoting DMAA at this time would be inappropriate.


DMAA is not a naturally occurring substance. It is created synthetically in pharmaceutical facilities. It was once used as a nasal decongestant.

Because of its properties of fat burning, potential energy, focus, strength, and alertness it has recently returned as an ingredient in weight loss and pre-workout dietary supplements.

Unhappy with this breakthrough, the FDA declared it to be illegal and hazardous. This notion appears to be supported by several reports and studies.

Because of the similarities in molecules, supplement manufacturers began to claim that their products were manufactured from the geranium plant.

The FDA was not convinced, and the debate is going on to this day. The FDA and everyone else need additional investigation before certifying it safe to use as it is a novel ingredient.

Before using any supplements, check your healthcare practitioner for permission, diagnosis, and accurate medical information.